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1

Myxobacterial secondary metabolites: bioactivities and modes-of-action

Weissman, Kira J., Müller, Rolf

Journal:

Natural Product Reports

Year:

2010

Language:

english

File:

PDF, 529 KB

english, 2010

2

The structural biology of biosynthetic megaenzymes

Weissman, Kira J

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 4.05 MB

english, 2015

3

Author Correction: Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis

Dorival, Jonathan, Risser, Fanny, Jacob, Christophe, Collin, Sabrina, Dräger, Gerald, Paris, Cédric, Chagot, Benjamin, Kirschning, Andreas, Gruez, Arnaud, Weissman, Kira J.

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 317 KB

english, 2019

4

Author Correction: Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis

Dorival, Jonathan, Risser, Fanny, Jacob, Christophe, Collin, Sabrina, DrÃ¤ger, Gerald, Paris, CÃ©dric, Chagot, Benjamin, Kirschning, Andreas, Gruez, Arnaud, Weissman, Kira J.

Journal:

Nature Communications

Year:

2020

Language:

english

File:

PDF, 306 KB

english, 2020

5

Structural elucidation studies of polyketide tetrasubstituted δ-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry

Kira J. Weissman, Gordon C. Kearney, Peter F. Leadlay, James Staunton

Journal:

Rapid Communications in Mass Spectrometry

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

6

Die Thioesterase der Polyketid-Synthase von Erythromycin: Einfluß der Acylkettenstruktur auf den Abkopplungsmechanismus der Substratanaloga von der Acyl-Enzym-Zwischenstufe

Kira J. Weissman, Cameron J. Smith, Ulf Hanefeld, Ranjana Aggarwal, Matthew Bycroft, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

1998

Language:

german

File:

PDF, 100 KB

german, 1998

7

The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates

Kira J. Weissman, Cameron J. Smith, Ulf Hanefeld, Ranjana Aggarwal, Matthew Bycroft, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

1998

Language:

english

File:

PDF, 95 KB

english, 1998

8

Produktion der Isochromanon-Antimykotika Ajudazol A und B in Chondromyces crocatus Cm c5: Biosynthesemaschinerie und Cytochrom-P450-Modifikationen

Kathrin Buntin, Shwan Rachid, Maren Scharfe, Helmut Blöcker, Kira J. Weissman, Rolf Müller

Journal:

Angewandte Chemie

Year:

2008

Language:

german

File:

PDF, 458 KB

german, 2008

9

Kristallstruktur einer molekularen Synthesemaschine

Kira J. Weissman, Rolf Müller

Journal:

Angewandte Chemie

Year:

2008

Language:

german

File:

PDF, 394 KB

german, 2008

10

Produktion der Isochromanon-Antimykotika Ajudazol A und B in Chondromyces crocatus Cm c5: Biosynthesemaschinerie und Cytochrom-P450-Modifikationen

Kathrin Buntin, Shwan Rachid, Maren Scharfe, Helmut Blöcker, Kira J. Weissman, Rolf Müller

Journal:

Angewandte Chemie

Year:

2009

Language:

german

File:

PDF, 155 KB

german, 2009

11

Production of the Antifungal Isochromanone Ajudazols A and B in Chondromyces crocatus Cm c5: Biosynthetic Machinery and Cytochrome P450 Modifications

Kathrin Buntin, Shwan Rachid, Maren Scharfe, Helmut Blöcker, Kira J. Weissman, Rolf Müller

Journal:

Angewandte Chemie International Edition

Year:

2008

Language:

english

File:

PDF, 460 KB

english, 2008

12

Crystal Structure of a Molecular Assembly Line

Kira J. Weissman, Rolf Müller

Journal:

Angewandte Chemie International Edition

Year:

2008

Language:

english

File:

PDF, 391 KB

english, 2008

13

Pretubulysin, a Potent and Chemically Accessible Tubulysin Precursor from Angiococcus disciformis

Angelika Ullrich, Yi Chai, Dominik Pistorius, Yasser A. Elnakady, Jennifer E. Herrmann, Kira J. Weissman, Uli Kazmaier, Rolf Müller

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 385 KB

english, 2009

14

Production of the Antifungal Isochromanone Ajudazols A and B in Chondromyces crocatus Cm c5: Biosynthetic Machinery and Cytochrome P450 Modifications

Kathrin Buntin, Shwan Rachid, Maren Scharfe, Helmut Blöcker, Kira J. Weissman, Rolf Müller

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 155 KB

english, 2009

15

Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea

Kira J. Weissman, Hui Hong, Markiyan Oliynyk, Alexis P. Siskos, Peter F. Leadlay

Journal:

Year:

2004

Language:

english

File:

PDF, 358 KB

english, 2004

16

Broad Substrate Specificity of Ketoreductases Derived from Modular Polyketide Synthases

Shilpa Bali, Helen M. O'Hare, Kira J. Weissman

Journal:

Year:

2006

Language:

english

File:

PDF, 233 KB

english, 2006

17

The Structural Basis for Docking in Modular Polyketide Biosynthesis

Kira J. Weissman

Journal:

Year:

2006

Language:

english

File:

PDF, 814 KB

english, 2006

18

Single Amino Acid Substitutions Alter the Efficiency of Docking in Modular Polyketide Biosynthesis

Kira J. Weissman

Journal:

Year:

2006

Language:

english

File:

PDF, 876 KB

english, 2006

19

Ketoreduction in Mycolactone Biosynthesis: Insight into Substrate Specificity and Stereocontrol from Studies of Discrete Ketoreductase Domains in vitro

Shilpa Bali, Kira J. Weissman

Journal:

Year:

2006

Language:

english

File:

PDF, 319 KB

english, 2006

20

Evidence for the Mode of Action of the Highly Cytotoxic Streptomyces Polyketide Kendomycin

Yasser A. Elnakady, Manfred Rohde, Florenz Sasse, Christina Backes, Andreas Keller, Hans-Peter Lenhof, Kira J. Weissman, Rolf Müller

Journal:

Year:

2007

Language:

english

File:

PDF, 964 KB

english, 2007

21

Covalent Linkage Mediates Communication between ACP and TE Domains in Modular Polyketide Synthases

Lucky Tran, Manuela Tosin, Jonathan B. Spencer, Peter F. Leadlay, Kira J. Weissman

Journal:

Year:

2008

Language:

english

File:

PDF, 797 KB

english, 2008

22

Protein–Protein Interactions in Multienzyme Megasynthetases

Kira J. Weissman, Rolf Müller

Journal:

Year:

2008

Language:

english

File:

PDF, 2.34 MB

english, 2008

23

Cover Picture: Evidence for the Mode of Action of the Highly Cytotoxic Streptomyces Polyketide Kendomycin (ChemBioChem 11/2007)

Yasser A. Elnakady, Manfred Rohde, Florenz Sasse, Christina Backes, Andreas Keller, Hans-Peter Lenhof, Kira J. Weissman, Rolf Müller

Journal:

Year:

2007

File:

PDF, 35 KB

2007

24

Improved Catalytic Activity of a Purified Multienzyme from a Modular Polyketide Synthase after Coexpression with Streptomyces Chaperonins in Escherichia coli.

Lorena Betancor, María-José Fernández , Kira J. Weissman , Peter F. Leadlay

Journal:

Year:

2008

Language:

english

File:

PDF, 350 KB

english, 2008

25

Taking a Closer Look at Fatty Acid Biosynthesis

Kira J. Weissman

Journal:

Year:

2008

Language:

english

File:

PDF, 540 KB

english, 2008

26

An Unusual Thioesterase Promotes Isochromanone Ring Formation in Ajudazol Biosynthesis

Kathrin Buntin, Kira J. Weissman, Rolf Müller

Journal:

Year:

2010

Language:

english

File:

PDF, 505 KB

english, 2010

27

Peering into the Black Box of Fungal Polyketide Biosynthesis

Kira J. Weissman

Journal:

Year:

2010

Language:

english

File:

PDF, 374 KB

english, 2010

28

Insights into Multienzyme Docking in Hybrid PKS–NRPS Megasynthetases Revealed by Heterologous Expression and Genetic Engineering

Yanyan Li , Kira J. Weissman, Rolf Müller

Journal:

Year:

2010

Language:

english

File:

PDF, 682 KB

english, 2010

29

Analysis of the Sorangicin Gene Cluster Reinforces the Utility of a Combined Phylogenetic/Retrobiosynthetic Analysis for Deciphering Natural Product Assembly by trans-AT PKS

Herbert Irschik , Maren Kopp , Kira J. Weissman, Kathrin Buntin, Jörn Piel, Rolf Müller

Journal:

Year:

2010

Language:

english

File:

PDF, 633 KB

english, 2010

30

ChemInform Abstract: Enantiospecific Synthesis of Analogues of the Diketide Intermediate of the Erythromycin Polyketide Synthase (PKS).

Rebecca C. Harris, Annabel L. Cutter, Kira J. Weissman, Ulf Hanefeld, Maire C. Timoney, James Staunton

Journal:

Year:

1999

File:

PDF, 29 KB

1999

31

ChemInform Abstract: Polyketide Biosynthesis: A Millennium Review

James Staunton, Kira J. Weissman

Journal:

Year:

2001

File:

PDF, 23 KB

2001

32

Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea.

Kira J. Weissman, Hui Hong, Markiyan Oliynyk, Alexis P. Siskos, Peter F. Leadlay

Journal:

Year:

2004

File:

PDF, 50 KB

2004

33

ChemInform Abstract: Pretubulysin (I), a Potent and Chemically Accessible Tubulysin Precursor from Angiococcus disciformis.

Angelika Ullrich, Yi Chai, Dominik Pistorius, Yasser A. Elnakady, Jennifer E. Herrmann, Kira J. Weissman, Uli Kazmaier, Rolf Mueller

Journal:

Year:

2009

File:

PDF, 18 KB

2009

34

ChemInform Abstract: Myxobacterial Secondary Metabolites: Bioactivities and Modes-of-Action

Kira J. Weissman, Rolf Mueller

Journal:

Year:

2010

File:

PDF, 14 KB

2010

35

A brief tour of myxobacterial secondary metabolism

Kira J. Weissman, Rolf Müller

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.17 MB

english, 2009

36

Plumbing New Depths in Drug Discovery

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 111 KB

english, 2004

37

A New Origin for Chartreusin

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 95 KB

english, 2005

38

Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

Alexandros P. Siskos, Abel Baerga-Ortiz, Shilpa Bali, Viktor Stein, Hassan Mamdani, Dieter Spiteller, Bojana Popovic, Jonathan B. Spencer, James Staunton, Kira J. Weissman, Peter F. Leadlay

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 205 KB

english, 2005

39

Evidence for a Protein-Protein Interaction Motif on an Acyl Carrier Protein Domain from a Modular Polyketide Synthase

Kira J. Weissman, Hui Hong, Bojana Popovic, Filip Meersman

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 612 KB

english, 2006

40

Insights into Polyether Biosynthesis from Analysis of the Nigericin Biosynthetic Gene Cluster in Streptomyces sp. DSM4137

Barbara M. Harvey, Tatiana Mironenko, Yuhui Sun, Hui Hong, Zixin Deng, Peter F. Leadlay, Kira J. Weissman, Stephen F. Haydock

Journal:

Chemistry & Biology

Year:

2007

Language:

english

File:

PDF, 1.13 MB

english, 2007

41

DKxanthene Biosynthesis—Understanding the Basis for Diversity-Oriented Synthesis in Myxobacterial Secondary Metabolism

Peter Meiser, Kira J. Weissman, Helge B. Bode, Daniel Krug, Jeroen S. Dickschat, Axel Sandmann, Rolf Müller

Journal:

Chemistry & Biology

Year:

2008

Language:

english

File:

PDF, 635 KB

english, 2008

42

Unusual Chemistry in the Biosynthesis of the Antibiotic Chondrochlorens

Shwan Rachid, Maren Scharfe, Helmut Blöcker, Kira J. Weissman, Rolf Müller

Journal:

Chemistry & Biology

Year:

2009

Language:

english

File:

PDF, 578 KB

english, 2009

43

Discovery of 23 Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004

Yi Chai, Dominik Pistorius, Angelika Ullrich, Kira J. Weissman, Uli Kazmaier, Rolf Müller

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 957 KB

english, 2010

44

Biosynthesis of Thuggacins in Myxobacteria: Comparative Cluster Analysis Reveals Basis for Natural Product Structural Diversity

Kathrin Buntin, Herbert Irschik, Kira J. Weissman, Eva Luxenburger, Helmut Blöcker, Rolf Müller

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 850 KB

english, 2010

45

Insights into Protein-Protein and Enzyme-Substrate Interactions in Modular Polyketide Synthases

Lucky Tran, R. William Broadhurst, Manuela Tosin, Andrea Cavalli, Kira J. Weissman

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 1013 KB

english, 2010

46

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase

Kira J. Weissman, Matthew Bycroft, Annabel L. Cutter, Ulf Hanefeld, Elizabeth J. Frost, Máire C. Timoney, Rebecca Harris, Sandeep Handa, Marc Roddis, James Staunton, Peter F. Leadlay

Journal:

Chemistry & Biology

Year:

1998

Language:

english

File:

PDF, 2.61 MB

english, 1998

47

Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase

Matthew Bycroft, Kira J. Weissman, James Staunton, Peter F. Leadlay

Journal:

Year:

2000

Language:

english

File:

PDF, 405 KB

english, 2000

48

The Structure of Docking Domains in Modular Polyketide Synthases

R.William Broadhurst, Daniel Nietlispach, Michael P Wheatcroft, Peter F Leadlay, Kira J Weissman

Journal:

Chemistry & Biology

Year:

2003

Language:

english

File:

PDF, 618 KB

english, 2003

49

Autonomous folding of interdomain regions of a modular polyketide synthase

Carsten D. Richter, David A. Stanmore, Ricardo N. Miguel, Martin C. Moncrieffe, Lucky Tran, Suzanne Brewerton, Filip Meersman, R. William Broadhurst, Kira J. Weissman

Journal:

Year:

2007

Language:

english

File:

PDF, 1.17 MB

english, 2007

50

Multienzyme docking in hybrid megasynthetases

Richter, Carsten D, Nietlispach, Daniel, Broadhurst, R William, Weissman, Kira J

Journal:

Nature Chemical Biology

Year:

2007

Language:

english

File:

PDF, 1.78 MB

english, 2007

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